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Molecule Parameter List for GTP-Ras

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
GTP-Ras participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001320

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

GTP-Ras acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
GTP-Rasfig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
01000No

GTP-Ras acting as a Substrate for an Enzyme in  
fig4_synapse Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
GAP  /
GAP-inact-ras
fig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
1.010410100explicit E-S complexSubstrate
GTP-Ras

Product
GDP-Ras

GTP-Ras acting as a Product of an Enzyme in  
fig4_synapse Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1GEF-Gprot-bg  /
GEF-bg_act-ras
fig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
0.5050510.024explicit E-S complexSubstrate
GDP-Ras

Product
GTP-Ras
2GEF*  /
GEF*-act-ras
fig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
0.5050510.024explicit E-S complexSubstrate
GDP-Ras

Product
GTP-Ras
3CaM-GEF  /
CaM-GEF-act-ras
fig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
0.5050510.024explicit E-S complexSubstrate
GDP-Ras

Product
GTP-Ras

GTP-Ras acting as a Substrate in a reaction in  
fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1Ras-act-craffig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 24
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.0208(uM)-Substrate
    GTP-Ras
    craf-1*

    Product
    Raf-GTP-Ras*
    2
  • Ras-intrinsic-GT
    Pase
  • fig4_synapse
    Accession No. : 3
    Ras
    Pathway No. : 25
    0.0001
    (s^-1)
    0
    (s^-1)
    --Substrate
    GTP-Ras

    Product
    GDP-Ras



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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