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Molecule Parameter List for CaM-GEF

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-GEF participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

CaM-GEF acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
CaM-GEFfig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
01000No

CaM-GEF acting as an Enzyme in  
fig4_synapse Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
CaM-GEF /
CaM-GEF-act-ras
fig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
0.5050510.024explicit E-S complexSubstrate
GDP-Ras

Product
GTP-Ras

CaM-GEF acting as a Product in a reaction in  
fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
CaM-bind-GEFfig4_synapse
Accession No. : 3
Ras
Pathway No. : 25
60
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.0167(uM)-Substrate
CaM-Ca4
inact-GEF

Product
CaM-GEF



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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