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Molecule Parameter List for PP1-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP1-active participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1150011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

PP1-active acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PP1-activefig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 1.81000No

    PP1-active acting as a Summed Molecule in  
    fig4_synapse Network
    Accession NamePathway NameTargetInput
    fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • tot_PP1-actPP1-active
    tot_PP1 has inputs from Deph-thr286, PP1-active, Deph-thr305, Deph-thr286c, Deph-thr286b,Deph-thr305. except PP1-active all other inputs are enzyme-substrate complex which is not currently supported by doqcs. But can be accessed from GENESIS file.

    PP1-active acting as an Enzyme in  
    fig4_synapse Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active /
    Deph-thr286
    fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 5.099070.354explicit E-S complexSubstrate
  • CaMKII-thr286*-C
    aM


    Product
    CaMKII-CaM
  • 2PP1-active /
    Deph-thr305
    fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 5.099070.354explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMKII-thr286
    3PP1-active /
    Deph-thr306
    fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 5.099070.354explicit E-S complexSubstrate
    CaMK-thr306

    Product
    CaMKII
    4PP1-active /
    Deph-thr286c
    fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 5.099070.354explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMK-thr306
    5PP1-active /
    Deph_thr286b
    fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 5.099070.354explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII

    PP1-active acting as a Substrate in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Inact-PP1fig4_synapse
    Accession No. : 3
    PP1
    Pathway No. : 28
    499.98
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    I1*
    PP1-active

    Product
    PP1-I1*

    PP1-active acting as a Product in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    dissoc-PP1-I1fig4_synapse
    Accession No. : 3
    PP1
    Pathway No. : 28
    1
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    PP1-I1

    Product
    I1
    PP1-active



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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