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Molecule Parameter List for tot_CaM_CaMKII | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| tot_CaM_CaMKII participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 2 | 2 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | CaMKII_noPKA_
model3 | 62 | Network |
Shared_Object_CaMKII_noPKA_model3, CaMKII, CaM,
PP1, PP2B, PP1_PSD | | This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA. |
tot_CaM_CaMKII acting as a Molecule in CaMKII_noPKA_model3 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | tot_CaM_CaMKII | CaMKII_noPKA_
model3
Accession No. : 62 | CaMKII
Pathway No. : 258 | 0 | 0.09 | No | | |
tot_CaM_CaMKII acting as a Summed Molecule in CaMKII_noPKA_model3 Network
tot_CaM_CaMKII acting as an Enzyme in CaMKII_noPKA_model3 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | tot_CaM_CaMKII /
CaM_act_305
| CaMKII_noPKA_
model3
Accession No. : 62 | CaMKII
Pathway No. : 258 | 226.998 | 6 | 4 | explicit E-S complex | Substrate
CaMKII-thr286
Product
CaMKII***
| | | Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5. | | 2 | tot_CaM_CaMKII /
CaM_act_286
| CaMKII_noPKA_
model3
Accession No. : 62 | CaMKII
Pathway No. : 258 | 226.998 | 0.5 | 4 | explicit E-S complex | Substrate
CaMKII-CaM
Product
CaMKII-thr286*-C
aM
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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