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Molecule Parameter List for PP1-I1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PP1-I1* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	2	0	0	0	4	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_model3	63	Network	Shared_Object_CaMKII_model3, CaMKII, CaM, PP1, PP2B, PP1_PSD, AC, PKA
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

PP1-I1 acting as a Molecule in CaMKII_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP1-I1	CaMKII_model3 Accession No. : 63	PP1 Pathway No. : 266	0	0.09	No

PP1-I1	CaMKII_model3 Accession No. : 63	PP1_PSD Pathway No. : 268	0	0.01	No

PP1-I1 acting as a Product of an Enzyme in CaMKII_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / PP2A-dephosph-PP 1-I*	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6
2	PP2A / PP2A-dephosph-PP 1-I*_ PSD	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6
3	CaM_Ca_n-CaNAB / dephosph-PP1-I*	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	4.97079	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
4	CaM_Ca_n-CaNAB / dephosph-PP1-I*_ PSD	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	4.97071	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1

PP1-I1 acting as a Substrate in a reaction in CaMKII_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	dissoc-PP1-I1	CaMKII_model3 Accession No. : 63	PP1 Pathway No. : 266	1 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate PP1-I1 Product I1 PP1-active
	Let us assume that the equil in this case is very far over to the right. This is probably safe.
2	dissoc-PP1-I1	CaMKII_model3 Accession No. : 63	PP1_PSD Pathway No. : 268	1 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate PP1-I1 Product I1 PP1-active_PSD
	Let us assume that the equil in this case is very far over to the right. This is probably safe.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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