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Molecule Parameter List for neurogranin*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001210

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

neurogranin* acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
neurogranin*fig4_synapse
Accession No. : 3
CaM
Pathway No. : 27
01000No

neurogranin* acting as a Substrate for an Enzyme in  
fig4_synapse Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
CaM(Ca)n-CaNAB  /
  • dephosph_
    neurogranin
  • fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 10.0120.673.98507explicit E-S complexSubstrate
    neurogranin*

    Product
    neurogranin

    neurogranin* acting as a Product of an Enzyme in  
    fig4_synapse Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKC-active  /
  • PKC-phosph-neuro
    granin
  • fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 28.62750.584.03448explicit E-S complexSubstrate
    neurogranin

    Product
    neurogranin*
    2PKC-active  /
  • PKC-phosph-ng-Ca
    M
  • fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 28.59480.354explicit E-S complexSubstrate
    neurogranin-CaM

    Product
    CaM
    neurogranin*

    neurogranin* acting as a Substrate in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • dephosph-neurogr
    anin
  • fig4_synapse
    Accession No. : 3
    CaM
    Pathway No. : 27
    0.005
    (s^-1)
    0
    (s^-1)
    --Substrate
    neurogranin*

    Product
    neurogranin



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.