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Molecule Parameter List for neurogranin

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001111

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

neurogranin acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
neurograninfig4_synapse
Accession No. : 3
CaM
Pathway No. : 27
101000No

neurogranin acting as a Substrate for an Enzyme in  
fig4_synapse Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
PKC-active  /
  • PKC-phosph-neuro
    granin
  • fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 28.62750.584.03448explicit E-S complexSubstrate
    neurogranin

    Product
    neurogranin*

    neurogranin acting as a Product of an Enzyme in  
    fig4_synapse Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    CaM(Ca)n-CaNAB  /
  • dephosph_
    neurogranin
  • fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 10.0120.673.98507explicit E-S complexSubstrate
    neurogranin*

    Product
    neurogranin

    neurogranin acting as a Substrate in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • neurogranin-bind
    -CaM
  • fig4_synapse
    Accession No. : 3
    CaM
    Pathway No. : 27
    0.3
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 3.3333(uM)-Substrate
    CaM
    neurogranin

    Product
    neurogranin-CaM

    neurogranin acting as a Product in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • dephosph-neurogr
    anin
  • fig4_synapse
    Accession No. : 3
    CaM
    Pathway No. : 27
    0.005
    (s^-1)
    0
    (s^-1)
    --Substrate
    neurogranin*

    Product
    neurogranin



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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