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Molecule Parameter List for R2C2-cAMP4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
R2C2-cAMP4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII_model363Network
Shared_Object_CaMKII_model3 CaMKII CaM 
PP1 PP2B PP1_PSD 
AC PKA 
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

R2C2-cAMP4 acting as a Molecule in  
CaMKII_model3 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
R2C2-cAMP4CaMKII_model3
Accession No. : 63
PKA
Pathway No. : 270
00.09No

R2C2-cAMP4 acting as a Substrate in a reaction in  
CaMKII_model3 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Release-C1CaMKII_model3
Accession No. : 63
PKA
Pathway No. : 270
60
(s^-1)
17.9998
(uM^-1 s^-1)
Kd(cb) = 0.3(uM)-Substrate
R2C2-cAMP4

Product
PKA-active
R2C-cAMP4
This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10

R2C2-cAMP4 acting as a Product in a reaction in  
CaMKII_model3 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • cAMP-bind-site-A
    2
  • CaMKII_model3
    Accession No. : 63
    PKA
    Pathway No. : 270
    75.0006
    (uM^-1 s^-1)
    32.5
    (s^-1)
    Kd(bf) = 0.4333(uM)-Substrate
    R2C2-cAMP3
    cAMP

    Product
    R2C2-cAMP4



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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