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Molecule Parameter List for tot_autonomous_CaMKII | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| tot_autonomous_CaMKII participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 2 | 2 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | CaMKII_model3 | 63 | Network |
Shared_Object_CaMKII_model3, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
AC, PKA | | This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs. |
tot_autonomous_CaMKII acting as a Molecule in CaMKII_model3 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | tot_autonomous_CaMKII | CaMKII_model3
Accession No. : 63 | CaMKII
Pathway No. : 264 | 2 | 0.09 | No | | |
tot_autonomous_CaMKII acting as a Summed Molecule in CaMKII_model3 Network
tot_autonomous_CaMKII acting as an Enzyme in CaMKII_model3 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | tot_autonomous_
CaMKII /
auton_305
| CaMKII_model3
Accession No. : 63 | CaMKII
Pathway No. : 264 | 350 | 6 | 4 | explicit E-S complex | Substrate
CaMKII-thr286
Product
CaMKII***
| | | See Hanson and Schulman again, for afterburst rates of phosph. | | 2 | tot_autonomous_
CaMKII /
auton_286
| CaMKII_model3
Accession No. : 63 | CaMKII
Pathway No. : 264 | 349.987 | 0.5 | 4 | explicit E-S complex | Substrate
CaMKII-CaM
Product
CaMKII-thr286*-C
aM
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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