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Molecule Parameter List for CaM_Ca_n-CaNAB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM_Ca_n-CaNAB participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences10380001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    weak_coupling
  • 65Network
    Shared_Object_AMPAR_CaMKII_weak_coupling CaMKII CaM 
    PP1 PP2B PP1_PSD 
    AMPAR PKA AC 
    AMPAR_memb PP1_CaMKII_PSD CaMKII_PSD 
    This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

    CaM_Ca_n-CaNAB acting as a Molecule in  
    AMPAR_CaMKII_weak_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaM_Ca_n-CaNAB
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    00.09No

    CaM_Ca_n-CaNAB acting as an Enzyme in  
    AMPAR_CaMKII_weak_coupling Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1CaM_Ca_n-CaNAB /
  • dephosph_
    neurogranin
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    10.0120.673.98507explicit E-S complexSubstrate
    neurogranin*

    Product
    neurogranin
        From Seki et al ABB 316(2):673-679
    2CaM_Ca_n-CaNAB /
    dephosph_inhib1
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.970790.344explicit E-S complexSubstrate
    I1*

    Product
    I1
    3CaM_Ca_n-CaNAB /
    dephosph-PP1-I*
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.970790.344explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
    4CaM_Ca_n-CaNAB /
  • dephosph_
    inhib1_PSD
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.970710.344explicit E-S complexSubstrate
    I1*

    Product
    I1
    5CaM_Ca_n-CaNAB /

  • dephosph-PP1-I*_
    PSD
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.970710.344explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
    6CaM_Ca_n-CaNAB /
    PP2B[17]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B

    Product
    A_B
    7CaM_Ca_n-CaNAB /
    PP2B[18]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B

    Product
    A831*_B
    8CaM_Ca_n-CaNAB /
    PP2B[19]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B831*

    Product
    A_B831*
    9CaM_Ca_n-CaNAB /
    PP2B[20]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B831*

    Product
    A831*_B831*
    10CaM_Ca_n-CaNAB /
    PP2B[21]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A_B845*

    Product
    A_B
    11CaM_Ca_n-CaNAB /
    PP2B[22]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*_B845*

    Product
    A831*_B
    12CaM_Ca_n-CaNAB /
    PP2B[23]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A_B831*845*

    Product
    A_B831*
    13CaM_Ca_n-CaNAB /
    PP2B[24]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*_B831*845*

    Product
    A831*_B831*
    14CaM_Ca_n-CaNAB /
    PP2B[25]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B845*

    Product
    A_B845*
    15CaM_Ca_n-CaNAB /
    PP2B[26]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B845*

    Product
    A831*_B845*
    16CaM_Ca_n-CaNAB /
    PP2B[27]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B831*845*

    Product
    A_B831*845*
    17CaM_Ca_n-CaNAB /
    PP2B[28]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
  • A835*845*_
    B835*845*


    Product
    A831*_B831*845*
  • 18CaM_Ca_n-CaNAB /
    PP2B[29]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B845*

    Product
    A845*_B
    19CaM_Ca_n-CaNAB /
    PP2B[30]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B845*

    Product
    A831*845*_B
    20CaM_Ca_n-CaNAB /
    PP2B[31]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B831*845*

    Product
    A845*_B831*
    21CaM_Ca_n-CaNAB /
    PP2B[32]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
  • A835*845*_
    B835*845*


    Product
    A831*845*_B831*
  • 22CaM_Ca_n-CaNAB /
    PP2B
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B845*

    Product
    A_B845*
    23CaM_Ca_n-CaNAB /
    PP2B[1]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B845*

    Product
    A845*_B
    24CaM_Ca_n-CaNAB /
    PP2B[2]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A_B845*

    Product
    A_B
    25CaM_Ca_n-CaNAB /
    PP2B[3]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B

    Product
    A_B
    26CaM_Ca_n-CaNAB /
    PP2B[4]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B845*

    Product
    A831*_B845*
    27CaM_Ca_n-CaNAB /
    PP2B[5]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B845*

    Product
    A831*845*_B
    28CaM_Ca_n-CaNAB /
    PP2B[6]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*_B845*

    Product
    A831*_B
    29CaM_Ca_n-CaNAB /
    PP2B[7]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B

    Product
    A831*_B
    30CaM_Ca_n-CaNAB /
    PP2B[8]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B831*845*

    Product
    A_B831*845*
    31CaM_Ca_n-CaNAB /
    PP2B[9]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B831*845*

    Product
    A845*_B831*
    32CaM_Ca_n-CaNAB /
    PP2B[10]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A_B831*845*

    Product
    A_B831*
    33CaM_Ca_n-CaNAB /
    PP2B[11]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A845*_B831*

    Product
    A_B831*
    34CaM_Ca_n-CaNAB /
    PP2B[12]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
  • A835*845*_
    B835*845*


    Product
    A831*_B831*845*
  • 35CaM_Ca_n-CaNAB /
    PP2B[13]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
  • A835*845*_
    B835*845*


    Product
    A831*845*_B831*
  • 36CaM_Ca_n-CaNAB /
    PP2B[14]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*845*_B831*

    Product
    A831*_B831*
    37CaM_Ca_n-CaNAB /
    PP2B[15]
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    4.9706124explicit E-S complexSubstrate
    A831*_B831*845*

    Product
    A831*_B831*
    38CaM_Ca_n-CaNAB /
  • dephosph_
    neurogranin_PSD
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    10.0120.673.98507explicit E-S complexSubstrate
  • neurogranin*_
    PSD


    Product
    neurogranin_PSD
  •     From Seki et al ABB 316(2):673-679

    CaM_Ca_n-CaNAB acting as a Product in a reaction in  
    AMPAR_CaMKII_weak_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMCa4-bind-CaNA
    B
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP2B
    Pathway No. : 285
    599.994
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.0017(uM)-Substrate
    CaM-Ca4
    CaNAB-Ca4

    Product
    CaM_Ca_n-CaNAB



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