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Molecule Parameter List for PDE1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PDE1 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

PDE1 acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PDE1fig4_synapse
Accession No. : 3
AC
Pathway No. : 31
21000No

PDE1 acting as an Enzyme in  
fig4_synapse Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
PDE1 /
PDE1
fig4_synapse
Accession No. : 3
AC
Pathway No. : 31
39.71.6674.0012explicit E-S complexSubstrate
cAMP

Product
AMP

PDE1 acting as a Substrate in a reaction in  
fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
CaM_bind_PDE1fig4_synapse
Accession No. : 3
AC
Pathway No. : 31
720
(uM^-1 s^-1)
5
(s^-1)
Kd(bf) = 0.0069(uM)-Substrate
CaM-Ca4
PDE1

Product
CaM.PDE1



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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