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Molecule Parameter List for Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences10000100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

Ca acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
Cafig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 0.081000No

    Ca acting as a Substrate in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PKC-act-by-Cafig4_synapse
    Accession No. : 3
    PKC
    Pathway No. : 20
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
    2PLA2-Ca-actfig4_synapse
    Accession No. : 3
    PLA2
    Pathway No. : 21
    1
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.1(uM)-Substrate
    Ca
    PLA2-cytosolic

    Product
    PLA2-Ca*
    3PLA2*-Ca-actfig4_synapse
    Accession No. : 3
    PLA2
    Pathway No. : 21
    6
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
    4Act-PLC-Cafig4_synapse
    Accession No. : 3
    PLCbeta
    Pathway No. : 22
    3
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.3333(uM)-Substrate
    Ca
    PLC

    Product
    PLC-Ca
    5PLC-Gq-bind-Cafig4_synapse
    Accession No. : 3
    PLCbeta
    Pathway No. : 22
    30
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.0333(uM)-Substrate
    Ca
    PLC-Gq

    Product
    PLC-Ca-Gq
    6CaM-TR2-bind-Cafig4_synapse
    Accession No. : 3
    CaM
    Pathway No. : 27
    72
    (uM^-2 s^-1)
    72
    (s^-1)
    Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
    7
  • CaM-TR2-Ca2-bind
    -Ca
  • fig4_synapse
    Accession No. : 3
    CaM
    Pathway No. : 27
    3.6
    (uM^-1 s^-1)
    10
    (s^-1)
    Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
    8CaM-Ca3-bind-Cafig4_synapse
    Accession No. : 3
    CaM
    Pathway No. : 27
    0.465
    (uM^-1 s^-1)
    10
    (s^-1)
    Kd(bf) = 21.5054(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
    9
  • Ca-bind-CaNAB-Ca
    2
  • fig4_synapse
    Accession No. : 3
    PP2B
    Pathway No. : 29
    3.6
    (uM^-2 s^-1)
    1
    (s^-1)
    Kd(af) = 0.527(uM)-Substrate
    Ca
    Ca
    CaNAB-Ca2

    Product
    CaNAB-Ca4
    10Ca-bind-CaNABfig4_synapse
    Accession No. : 3
    PP2B
    Pathway No. : 29
    10008
    (uM^-2 s^-1)
    1
    (s^-1)
    Kd(af) = 0.01(uM)-Substrate
    Ca
    Ca
    CaNAB

    Product
    CaNAB-Ca2



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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