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Molecule Parameter List for BetaGamma

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
BetaGamma participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000022

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

BetaGamma acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
BetaGammafig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 01000No

    BetaGamma acting as a Substrate in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Trimerize-Gfig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    6
    (uM^-1 s^-1)
    0
    (s^-1)
    --Substrate
    BetaGamma
    G*GDP

    Product
    G-GDP
    2bg-act-GEFfig2_egfr
    Accession No. : 1
    Ras
    Pathway No. : 7
    6
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.1667(uM)-Substrate
    BetaGamma
    inact-GEF

    Product
    GEF-Gprot-bg

    BetaGamma acting as a Product in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Basal-Act-Gfig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    0.0001
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    G-GDP

    Product
    BetaGamma
    G*GTP
    2Activate-Gqfig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    0.01
    (s^-1)
    0
    (uM^-2 s^-1)
    --Substrate
    Rec-Glu-Gq

    Product
    BetaGamma
    G*GTP
    Rec-Glu



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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