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Molecule Parameter List for G*GTP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
G*GTP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000032

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

G*GTP acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
G*GTPfig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 01000No

    G*GTP acting as a Substrate in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Act-PLC-by-Gqfig2_egfr
    Accession No. : 1
    PLCbeta
    Pathway No. : 4
    25.2
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.0397(uM)-Substrate
    G*GTP
    PLC-Ca

    Product
    PLC-Ca-Gq
    2PLC-bind-Gqfig2_egfr
    Accession No. : 1
    PLCbeta
    Pathway No. : 4
    2.52
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.3968(uM)-Substrate
    G*GTP
    PLC

    Product
    PLC-Gq
    3Inact-Gfig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    0.0133
    (s^-1)
    0
    (s^-1)
    --Substrate
    G*GTP

    Product
    G*GDP

    G*GTP acting as a Product in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Basal-Act-Gfig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    0.0001
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    G-GDP

    Product
    BetaGamma
    G*GTP
    2Activate-Gqfig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    0.01
    (s^-1)
    0
    (uM^-2 s^-1)
    --Substrate
    Rec-Glu-Gq

    Product
    BetaGamma
    G*GTP
    Rec-Glu



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.