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Molecule Parameter List for neurogranin-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin-CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
  • 78Network
    Shared_Object_Ajay_Bhalla_2004_Feedback_Tuning PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC 
    This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a.

    neurogranin-CaM acting as a Molecule in  
    Ajay_Bhalla_2004_Feedback_Tuning Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    neurogranin-CaM
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning

    Accession No. : 78
  • CaM
    Pathway No. : 358
    01.5No

    neurogranin-CaM acting as a Substrate for an Enzyme in  
    Ajay_Bhalla_2004_Feedback_Tuning Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PKC-active  /
  • PKC-phosph-ng-Ca
    M
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning

    Accession No. : 78
  • Shared_Object_
    Ajay_Bhalla_
    2004_Feedback_
    Tuning

    Pathway No. : 347
  • 28.59480.354explicit E-S complexSubstrate
    neurogranin-CaM

    Product
    CaM
    neurogranin*
    Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993

    neurogranin-CaM acting as a Product in a reaction in  
    Ajay_Bhalla_2004_Feedback_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • neurogranin-bind
    -CaM
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning

    Accession No. : 78
  • CaM
    Pathway No. : 358
    0.3
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 3.3334(uM)-Substrate
    CaM
    neurogranin

    Product
    neurogranin-CaM
    Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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