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Molecule Parameter List for PIP2-Ca-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PIP2-Ca-PLA2* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • mkp1_feedback_
    effects
  • 4Network
    Shared_Object_mkp1_feedback_effects Sos PKC 
    MAPK PLA2 Ras 
    PDGFR 
    This is a network involving the MAPK-PKC feedback loop with input from the PDGFR in the synapse. The distinctive feature of this model is that it includes MKP-1 induction by MAPK, and the consequent inhibitory regulation of MAPK and the feedback loop. Lots of interesting dynamics arise from this. This link provides supplementary material for the paper Bhalla US et al. Science (2002) 297(5583):1018-23. In the form of several example simulations and demos for the figures in the paper.

    PIP2-Ca-PLA2* acting as a Molecule in  
    mkp1_feedback_effects Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PIP2-Ca-PLA2*
  • mkp1_feedback_
    effects

    Accession No. : 4
  • PLA2
    Pathway No. : 36
    01000No

    PIP2-Ca-PLA2* acting as an Enzyme in  
    mkp1_feedback_effects Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PIP2-Ca-PLA2* /
    kenz
  • mkp1_feedback_
    effects

    Accession No. : 4
  • PLA2
    Pathway No. : 36
    20364explicit E-S complexSubstrate
    APC

    Product
    AA
    Based on AA generation by different stimuli according to Leslie and Channon 1990 BBA 1045:261

    PIP2-Ca-PLA2* acting as a Product in a reaction in  
    mkp1_feedback_effects Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • PIP2-Ca-PLA2-act
  • mkp1_feedback_
    effects

    Accession No. : 4
  • PLA2
    Pathway No. : 36
    0.012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 8.3333(uM)-Substrate
    PLA2-Ca*
    temp-PIP2

    Product
    PIP2-Ca-PLA2*
    Synergistic activation of PLA2 by Ca and PIP2. Again from Leslie and Channon 1990 BBA 1045:261



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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