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Molecule Parameter List for Gs-alpha | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| Gs-alpha participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 3 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2004_Feedback_
Tuning | 78 | Network |
Shared_Object_Ajay_Bhalla_2004_Feedback_Tuning, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaMKII, CaM,
PP1, PP2B, PKA,
AC | | This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a. |
Gs-alpha acting as a Molecule in Ajay_Bhalla_2004_Feedback_Tuning Network
Gs-alpha acting as a Substrate in a reaction in Ajay_Bhalla_2004_Feedback_Tuning Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Gs-bind-AC2 | Ajay_Bhalla_
2004_Feedback_
Tuning
Accession No. : 78 | AC
Pathway No. : 362 | 499.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.002(uM) | - | Substrate
AC2
Gs-alpha
Product
AC2-Gs
| | | Half-max at around 3nM = kb/kf from fig 5 in Feinstein et al PNAS USA 88 10173-10177 1991 kf = kb/1800 = 5.56e-4 kb Ofer's thesis data indicates it is more like 2 nM. kf = kb/1200 = 8.33e-4 | | 2 | Gs-bind-AC1 | Ajay_Bhalla_
2004_Feedback_
Tuning
Accession No. : 78 | AC
Pathway No. : 362 | 126
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.0079(uM) | - | Substrate
AC1
Gs-alpha
Product
AC1-Gs
| | | Half-max 8nM from Tang et al JBC266:13 8595-8603 kb/kf = 8 nM = 4800#/cell so kf = kb * 2.08e-4 | | 3 | Gs-bind-AC2* | Ajay_Bhalla_
2004_Feedback_
Tuning
Accession No. : 78 | AC
Pathway No. : 362 | 833.283
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.0012(uM) | - | Substrate
AC2*
Gs-alpha
Product
AC2*-Gs
| | | kb/kf = 1.2 nM so kf = kb/720 = 1.3888 * kb. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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