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Molecule Parameter List for G-GDP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
G-GDP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000031

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

G-GDP acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
G-GDPfig2_egfr
Accession No. : 1
Gq
Pathway No. : 5
11000No

G-GDP acting as a Substrate in a reaction in  
fig2_egfr Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1Basal-Act-Gfig2_egfr
Accession No. : 1
Gq
Pathway No. : 5
0.0001
(s^-1)
0
(uM^-1 s^-1)
--Substrate
G-GDP

Product
BetaGamma
G*GTP
2Rec-Glu-bind-Gqfig2_egfr
Accession No. : 1
Gq
Pathway No. : 5
0.006
(uM^-1 s^-1)
0.0001
(s^-1)
Kd(bf) = 0.0167(uM)-Substrate
G-GDP
Rec-Glu

Product
Rec-Glu-Gq
3Rec-bind-Gqfig2_egfr
Accession No. : 1
Gq
Pathway No. : 5
0.6
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 1.6667(uM)-Substrate
G-GDP
mGluR

Product
Rec-Gq

G-GDP acting as a Product in a reaction in  
fig2_egfr Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Trimerize-Gfig2_egfr
Accession No. : 1
Gq
Pathway No. : 5
6
(uM^-1 s^-1)
0
(s^-1)
--Substrate
BetaGamma
G*GDP

Product
G-GDP



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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