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Molecule Parameter List for CaM-Ca4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-Ca4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_PKM
    		• 80Network
    Shared_Object_Ajay_Bhalla_2007_PKM,  PKC,  MAPK,  
    Ras,  CaM,  PKM 
    This is a non-bistable model of ERKII signaling that also incorporates PKM synthesis triggered by Ca influx. It is a simplified variant of the model of Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80.

    CaM-Ca4 acting as a Molecule in      Ajay_Bhalla_2007_PKM Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CaM-Ca4
  • Ajay_Bhalla_
    2007_PKM
    Accession No. : 80
    		• CaM
    Pathway No. : 373    		01.5No

    CaM-Ca4 acting as a Substrate in a reaction in      Ajay_Bhalla_2007_PKM Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1CaM-bind-GEF
  • Ajay_Bhalla_
    2007_PKM
    Accession No. : 80
    		• Ras
    Pathway No. : 372    		199.999
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    2trigger_PKM
  • Ajay_Bhalla_
    2007_PKM
    Accession No. : 80
    		• PKM
    Pathway No. : 374    		9.9999
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.1(uM)-Substrate
    CaM-Ca4
    Ca_detector

    Product
  • Ca.detector_
    complex

    • CaM-Ca4 acting as a Product in a reaction in      Ajay_Bhalla_2007_PKM Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_PKM
    Accession No. : 80
    		• CaM
    Pathway No. : 373    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5053(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
    Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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