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Molecule Parameter List for mGluR

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
mGluR participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

mGluR acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
mGluRfig2_egfr
Accession No. : 1
Gq
Pathway No. : 5
0.31000No

mGluR acting as a Substrate in a reaction in  
fig2_egfr Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1
  • RecLigandBinding
  • fig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    16.8
    (uM^-1 s^-1)
    10
    (s^-1)
    Kd(bf) = 0.5952(uM)-Substrate
    Glu
    mGluR

    Product
    Rec-Glu
    2Rec-bind-Gqfig2_egfr
    Accession No. : 1
    Gq
    Pathway No. : 5
    0.6
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 1.6667(uM)-Substrate
    G-GDP
    mGluR

    Product
    Rec-Gq



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.