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Molecule Parameter List for craf-1**

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
craf-1** participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_MKP1_
    oscillation
  • 9Network
    Shared_Object_MAPK_MKP1_oscillation PKC MAPK 
    PLA2 Ras 
    This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

    craf-1** acting as a Molecule in  
    MAPK_MKP1_oscillation Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    craf-1**
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • MAPK
    Pathway No. : 61
    01000No
    Negative feedback by MAPK* by hyperphosphorylating craf-1* gives rise to this pool. Ueki et al JBC 269(22):15756-15761, 1994

    craf-1** acting as a Substrate for an Enzyme in  
    MAPK_MKP1_oscillation Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PPhosphatase2A  /
    craf**-deph
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • Shared_Object_
    MAPK_MKP1_
    oscillation

    Pathway No. : 59
  • 15.656664.16667explicit E-S complexSubstrate
    craf-1**

    Product
    craf-1*
    Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of craf, so this is there to dephosphorylate it. Identity of phosphatase is not known to me, but it may be PP2A like the rest, so I have made it so.

    craf-1** acting as a Product of an Enzyme in  
    MAPK_MKP1_oscillation Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    MAPK*  /
    MAPK*-feedback
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • Shared_Object_
    MAPK_MKP1_
    oscillation

    Pathway No. : 59
  • 25.641104explicit E-S complexSubstrate
    craf-1*

    Product
    craf-1**
    Ueki et al JBC 269(22):15756-15761 show the presence of this step, but not the rate consts, which are derived from Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the MAPK* notes.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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