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Molecule Parameter List for RGR

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
RGR participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_MKP1_
    oscillation
    		• 9Network
    Shared_Object_MAPK_MKP1_oscillation,  PKC,  MAPK,  
    PLA2,  Ras 
    This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

    RGR acting as a Molecule in      MAPK_MKP1_oscillation Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    RGR
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• MAPK
    Pathway No. : 61    		01000No

    RGR acting as an Enzyme in      MAPK_MKP1_oscillation Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1RGR /
    RGR.1
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• MAPK
    Pathway No. : 61    		0.1590910.1054explicit E-S complexSubstrate
    MAPKK

    Product
    MAPKK-ser
        Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
    2RGR /
    RGR.2
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• MAPK
    Pathway No. : 61    		0.1590910.1054explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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