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Molecule Parameter List for MKP-1**

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MKP-1** participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020120

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_MKP1_
    oscillation
  • 9Network
    Shared_Object_MAPK_MKP1_oscillation PKC MAPK 
    PLA2 Ras 
    This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

    MKP-1** acting as a Molecule in  
    MAPK_MKP1_oscillation Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    MKP-1**
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • MAPK
    Pathway No. : 61
    01000No
    3 Feb 2000. Same enz activity as MKP-1, but different degradation rates. Brondello et al Science 286:2514 1999 4 Feb. Actually this form is doubly phosphorylated.

    MKP-1** acting as an Enzyme in  
    MAPK_MKP1_oscillation Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MKP-1** /
    MKP1*-tyr-deph
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • MAPK
    Pathway No. : 61
    0.066666714Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S
    Substrate
    MAPK-tyr

    Product
    MAPK
        3 Feb 2000. Same rates as MKP-1.
    2MKP-1** /
    MKP1*-thr-deph
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • MAPK
    Pathway No. : 61
    0.066666714Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S
    Substrate
    MAPK*

    Product
    MAPK-tyr
        3 Feb 2000. Same rates as MKP1

    MKP-1** acting as a Product of an Enzyme in  
    MAPK_MKP1_oscillation Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    MAPK*  /
    MKP-1-phosph2
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • Shared_Object_
    MAPK_MKP1_
    oscillation

    Pathway No. : 59
  • 25.64114explicit E-S complexSubstrate
    MKP-1-ser359*

    Product
    MKP-1**
    3 Feb 2000. See Brondello et al Science 286:2514 1999. Rates assumed standard MAPK rates based on Sanghera et al JBC 265(1):53-57 1990. 24 Apr 2K, based on 12 Feb 2K: Scaled x0.1 to 3.25e-7,4,1

    MKP-1** acting as a Substrate in a reaction in  
    MAPK_MKP1_oscillation Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1turnover_MKP1**
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • MAPK
    Pathway No. : 61
    0.0001
    (s^-1)
    0
    (s^-1)
    --Substrate
    MKP-1**

    Product
    Ubiquitination
      3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff.
    2MKP-1**dephosph
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • MAPK
    Pathway No. : 61
    0.01
    (s^-1)
    0
    (s^-1)
    --Substrate
    MKP-1**

    Product
    MKP-1-ser359*
      24 Apr 2K, based on 12 Feb 2K: Scaled up 10x to kf=0.01, kb=0



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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