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Molecule Parameter List for DAG-Ca-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DAG-Ca-PLA2* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_MKP1_
    oscillation
  • 9Network
    Shared_Object_MAPK_MKP1_oscillation PKC MAPK 
    PLA2 Ras 
    This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

    DAG-Ca-PLA2* acting as a Molecule in  
    MAPK_MKP1_oscillation Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    DAG-Ca-PLA2*
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • PLA2
    Pathway No. : 62
    01000No

    DAG-Ca-PLA2* acting as an Enzyme in  
    MAPK_MKP1_oscillation Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    DAG-Ca-PLA2* /
    kenz
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • PLA2
    Pathway No. : 62
    20604explicit E-S complexSubstrate
    APC

    Product
    AA
    10 X raise oct 22 12 X raise oct 24 + conversion to k2 =4 * k3

    DAG-Ca-PLA2* acting as a Product in a reaction in  
    MAPK_MKP1_oscillation Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    DAG-Ca-PLA2-act
  • MAPK_MKP1_
    oscillation

    Accession No. : 9
  • PLA2
    Pathway No. : 62
    0.003
    (uM^-1 s^-1)
    4
    (s^-1)
    Kd(bf) = 1333.3333(uM)-Substrate
    DAG
    PLA2-Ca*

    Product
    DAG-Ca-PLA2*
    27 June 1996 Scaled kf down by 0.015 from 3.33e-7 to 5e-9 to fit with revised DAG estimates and use of mole-fraction to calculate eff on PLA2.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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