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Molecule Parameter List for Ca.PLCbeta | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
Ca.PLCbeta acting as a Molecule in PLCbeta1 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Ca.PLCbeta | PLCbeta1
Accession No. : 13 | PLCbeta
Pathway No. : 67 | 0 | 0.0016667 | No | | 6 Nov 2001 The enzyme activity is observed only when it combines with Ca and becomes Calcium bound form of enzyme complex.All the curves obtained are in the presence of different concentrations of Calcium by I. Litosch, Biochem.,2000, 39,7736-7743. |
Ca.PLCbeta acting as an Enzyme in PLCbeta1 Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Ca.PLCbeta /
Ca.PLCbeta
| PLCbeta1
Accession No. : 13 | PLCbeta
Pathway No. : 67 | 10 | 7 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
PIP2
Product
DAG
IP3
| | 3 Nov 2001 Sternweis et al Phil Trans Soc R Lond B Biol Sci 1992 Apr 29; 336(1276);35-41;discussion 41-2. The Km and Vmax values according to Sternweis et al. The Km is fixed to 10uM since there is absence of Gq and so is the Vmax values which is fixed at 7uM since the Km obtained varies between 5 and 20uM and Vmax between 7 and 23umol/min/mg depending on the presence and absence of Gq. |
Ca.PLCbeta acting as a Substrate in a reaction in PLCbeta1 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Gq-bind-Ca.PLCbe
ta | PLCbeta1
Accession No. : 13 | PLCbeta
Pathway No. : 67 | 50
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.02(uM) | - | Substrate
Ca.PLCbeta
Gq
Product
Gq.Ca.PLCbeta
| | | 6 Nov 2001 The Kf and Kb values were fixed according to the response curves obtained from I. Litosch, Biochem., 2000, 39, 7736-7743. | | 2 | PA-bind-Ca.PLCbe
ta | PLCbeta1
Accession No. : 13 | PLCbeta
Pathway No. : 67 | 1
(uM^-1 s^-1) | 8
(s^-1) | Kd(bf) = 8(uM) | - | Substrate
Ca.PLCbeta
PA
Product
PA.Ca.PLCbeta
| | | 6 Nov 2001 The Kf and Kb values were fixed according to the dose response curves obtained from I. Litosch, Biochem., 2000, 39, 7736-7743. |
Ca.PLCbeta acting as a Product in a reaction in PLCbeta1 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Ca_bind_PLCbeta | PLCbeta1
Accession No. : 13 | PLCbeta
Pathway No. : 67 | 1
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 1(uM) | - | Substrate
Ca
PLCbeta
Product
Ca.PLCbeta
| | 6 Nov 2001 The Kf and Kb values were fixed according to the dose response curves obtained from I.Litosch, Biochem., 2000, 39, 7736-7743. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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