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Molecule Parameter List for Raf-GTP-Ras*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Raf-GTP-Ras* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

Raf-GTP-Ras* acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
Raf-GTP-Ras*fig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
01000No

Raf-GTP-Ras* acting as an Enzyme in  
fig2_egfr Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1Raf-GTP-Ras* /
Raf-GTP-Ras*.1
fig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
0.1590910.1054explicit E-S complexSubstrate
MAPKK

Product
MAPKK-ser
2Raf-GTP-Ras* /
Raf-GTP-Ras*.2
fig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
0.1590910.1054explicit E-S complexSubstrate
MAPKK-ser

Product
MAPKK*

Raf-GTP-Ras* acting as a Product in a reaction in  
fig2_egfr Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Ras-act-craffig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 24
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.0208(uM)-Substrate
    GTP-Ras
    craf-1*

    Product
    Raf-GTP-Ras*



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.