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Molecule Parameter List for Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
PLCbeta113Pathway
PLCbeta 
This is a model of PLCbeta1 in the bovine brain membranes as stimulated by Ca, Gq and PA.
The primary data sources are Irene Litosch Biochemistry (2000) 39(26):7736-43,
Sternweis PC et al. Philos Trans R Soc Lond B Biol Sci. (1992) 336(1276):35-41 and
Smrcka AV et al. Science (1991) 251(4995):804-7.

Ca acting as a Molecule in  
PLCbeta1 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
CaPLCbeta1
Accession No. : 13
PLCbeta
Pathway No. : 67
0.090.0016667Yes
21 Jul 2001 Concn varies betwn 0.001 to 10 uM. The Concentration of Ca is obtained from I. Litosch, Biochem., 2000, 39,7736-7743. The concentration of Ca is buffered to different levels and rate of binding of enzyme is noted.But here it is set to 0.09uM which is the basal level of Calcium.

Ca acting as a Substrate in a reaction in  
PLCbeta1 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Ca_bind_PLCbetaPLCbeta1
Accession No. : 13
PLCbeta
Pathway No. : 67
1
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 1(uM)-Substrate
Ca
PLCbeta

Product
Ca.PLCbeta
6 Nov 2001 The Kf and Kb values were fixed according to the dose response curves obtained from I.Litosch, Biochem., 2000, 39, 7736-7743.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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