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Molecule Parameter List for PIP2-Ca-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PIP2-Ca-PLA2* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Synaptic_
    Network
  • 16Network
    Shared_Object_Synaptic_Network PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC CaRegulation 
    This model is an annotated version of the synaptic signaling network.
    The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
    Bhalla US Biophys J. 2002 Aug;83(2):740-52
    Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

    PIP2-Ca-PLA2* acting as a Molecule in  
    Synaptic_Network Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PIP2-Ca-PLA2*
  • Synaptic_
    Network

    Accession No. : 16
  • PLA2
    Pathway No. : 72
    01000No
    Activated form of PLA2 with PIP2 and Ca bound.

    PIP2-Ca-PLA2* acting as an Enzyme in  
    Synaptic_Network Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PIP2-Ca-PLA2* /
    kenz
  • Synaptic_
    Network

    Accession No. : 16
  • PLA2
    Pathway No. : 72
    20364explicit E-S complexSubstrate
    APC

    Product
    AA
    Based on AA generation by different stimuli according to Leslie and Channon 1990 BBA 1045:261

    PIP2-Ca-PLA2* acting as a Product in a reaction in  
    Synaptic_Network Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • PIP2-Ca-PLA2-act
  • Synaptic_
    Network

    Accession No. : 16
  • PLA2
    Pathway No. : 72
    0.012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 8.3333(uM)-Substrate
    PLA2-Ca*
    temp-PIP2

    Product
    PIP2-Ca-PLA2*
    Synergistic activation of PLA2 by Ca and PIP2. Again from Leslie and Channon 1990 BBA 1045:261



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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