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Molecule Parameter List for DAG-Ca-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DAG-Ca-PLA2* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Synaptic_
    Network
  • 16Network
    Shared_Object_Synaptic_Network PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC CaRegulation 
    This model is an annotated version of the synaptic signaling network.
    The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
    Bhalla US Biophys J. 2002 Aug;83(2):740-52
    Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

    DAG-Ca-PLA2* acting as a Molecule in  
    Synaptic_Network Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    DAG-Ca-PLA2*
  • Synaptic_
    Network

    Accession No. : 16
  • PLA2
    Pathway No. : 72
    01000No
    Active form of PLA2 with DAG and Ca bound. DAG and Ca act in combination hence the need for this form in the model. Leslie and Channon (199) BBA 1045:261-270

    DAG-Ca-PLA2* acting as an Enzyme in  
    Synaptic_Network Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    DAG-Ca-PLA2* /
    kenz
  • Synaptic_
    Network

    Accession No. : 16
  • PLA2
    Pathway No. : 72
    20604explicit E-S complexSubstrate
    APC

    Product
    AA
    Based on Leslie and Channon 1990 BBA 1045:261.

    DAG-Ca-PLA2* acting as a Product in a reaction in  
    Synaptic_Network Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    DAG-Ca-PLA2-act
  • Synaptic_
    Network

    Accession No. : 16
  • PLA2
    Pathway No. : 72
    0.003
    (uM^-1 s^-1)
    4
    (s^-1)
    Kd(bf) = 1333.3333(uM)-Substrate
    DAG
    PLA2-Ca*

    Product
    DAG-Ca-PLA2*
    Synergistic activation of PLA2 by Ca and DAG. Based on Leslie and Channon 1990 BBA 1045:261 The Kd is rather large and may reflect the complications in measuring DAG. For this model it is not critical since DAG is held fixed.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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