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Molecule Parameter List for inact-GEF

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
inact-GEF participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002022

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

inact-GEF acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
inact-GEFfig2_egfr
Accession No. : 1
Ras
Pathway No. : 7
0.11000No

inact-GEF acting as a Substrate for an Enzyme in  
fig2_egfr Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1PKC-active  /
PKC-act-GEF
fig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 3.3333344explicit E-S complexSubstrate
    inact-GEF

    Product
    GEF*
    2PKA-active  /
    PKA-phosph-GEF
    fig2_egfr
    Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 7.594explicit E-S complexSubstrate
    inact-GEF

    Product
    inact-GEF*

    inact-GEF acting as a Substrate in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1bg-act-GEFfig2_egfr
    Accession No. : 1
    Ras
    Pathway No. : 7
    6
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.1667(uM)-Substrate
    BetaGamma
    inact-GEF

    Product
    GEF-Gprot-bg
    2CaM-bind-GEFfig2_egfr
    Accession No. : 1
    Ras
    Pathway No. : 7
    60
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.0167(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF

    inact-GEF acting as a Product in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1dephosph-GEFfig2_egfr
    Accession No. : 1
    Ras
    Pathway No. : 7
    1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GEF*

    Product
    inact-GEF
    2
  • dephosph-inact-G
    EF*
  • fig2_egfr
    Accession No. : 1
    Ras
    Pathway No. : 7
    1
    (s^-1)
    0
    (s^-1)
    --Substrate
    inact-GEF*

    Product
    inact-GEF



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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