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Molecule Parameter List for IP3R*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3R* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Synaptic_
    Network
  • 16Network
    Shared_Object_Synaptic_Network PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC CaRegulation 
    This model is an annotated version of the synaptic signaling network.
    The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
    Bhalla US Biophys J. 2002 Aug;83(2):740-52
    Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

    IP3R* acting as a Molecule in  
    Synaptic_Network Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3R*
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    01000No
    This is the ligand-bound form of the IP3 receptor.

    IP3R* acting as a Product in a reaction in  
    Synaptic_Network Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    IP3Rbind
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    0.05
    (uM^-3 s^-1)
    1
    (s^-1)
    Kd(af) = 2.7144(uM)-Substrate
    IP3
    IP3
    IP3
    IP3R

    Product
    IP3R*
    Based on Lauffenburger and Linderman 1993 Receptors page 200. The binding of IP3 in this reaction has a Hill coeff of 3. The eqns of Mahama and Linderman (cited in the book as 1993 a) are equivalent to the binding all occurring in a single step, so that is how I am doing it in this version. Their Ki1 is 0.07 uM. Lots of other data sources: Ramos-Franco et al 1998 Biophys J 75:834-839 have Ca sensitivity curves. At 250 nM free Ca, the EC50 for type 1 is 58 nM and type 2 is 194 nM. Type 3 would be about 2 uM according to Newton et al 1994 JBC 268(46):28613-28619 For the purposes of this model we use a Kd of 2.7 uM which is high but may be OK at low calcium. The details of Ca interaction with the IP3R are not included in this model.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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