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Molecule Parameter List for inact_cap_entry

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
inact_cap_entry participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Synaptic_
    Network
  • 16Network
    Shared_Object_Synaptic_Network PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC CaRegulation 
    This model is an annotated version of the synaptic signaling network.
    The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
    Bhalla US Biophys J. 2002 Aug;83(2):740-52
    Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

    inact_cap_entry acting as a Molecule in  
    Synaptic_Network Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    inact_cap_entry
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    01000No
    This represents the portion of the capacitive-Ca entry channel which is blocked when there is lots of Ca sequestered in the stores.

    inact_cap_entry acting as a Product in a reaction in  
    Synaptic_Network Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • inactivate_cap_
    Ca
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    0
    (#^-2 s^-1)
    1
    (s^-1)
    Not applicable**-Substrate
    Ca-sequester
    Ca-sequester
  • capacitive_Ca_
    entry*


    Product
    inact_cap_entry
  • The Kd is set to about 3 uM, so that at resting Ca the capacitive Ca entry is almost blocked. A 2nd order response makes the response steep.
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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