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Molecule Parameter List for SHC*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
SHC* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000120

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

SHC* acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
SHC*fig2_egfr
Accession No. : 1
EGFR
Pathway No. : 8
01000No

SHC* acting as a Product of an Enzyme in  
fig2_egfr Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
L.EGFR  /
phosph_Shc
fig2_egfr
Accession No. : 1
EGFR
Pathway No. : 8
0.8333330.24explicit E-S complexSubstrate
SHC

Product
SHC*

SHC* acting as a Substrate in a reaction in  
fig2_egfr Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1dephosph_Shcfig2_egfr
Accession No. : 1
EGFR
Pathway No. : 8
0.0017
(s^-1)
0
(s^-1)
--Substrate
SHC*

Product
SHC
2
  • Shc_bind_
    Sos.Grb2
  • fig2_egfr
    Accession No. : 1
    Sos
    Pathway No. : 9
    0.5
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.2(uM)-Substrate
    SHC*
    Sos.Grb2

    Product
    Shc*.Sos.Grb2



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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