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Molecule Parameter List for temp-PIP2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
temp-PIP2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

temp-PIP2 acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
temp-PIP2fig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 2.51000Yes

    temp-PIP2 acting as a Substrate in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PIP2-PLA2-actfig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    0.0012
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 416.6667(uM)-Substrate
    PLA2-cytosolic
    temp-PIP2

    Product
    PIP2-PLA2*
    2
  • PIP2-Ca-PLA2-act
  • fig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    0.012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 8.3333(uM)-Substrate
    PLA2-Ca*
    temp-PIP2

    Product
    PIP2-Ca-PLA2*



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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