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Molecule Parameter List for PIP2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PIP2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1004000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

PIP2 acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PIP2fig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 101000Yes

    PIP2 acting as a Substrate for an Enzyme in  
    fig2_egfr Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PLC-Ca  /
    PLC-Ca
    fig2_egfr
    Accession No. : 1
    PLCbeta
    Pathway No. : 4
    19.8413104explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3
    2PLC-Ca-Gq  /
    PLCb-Ca-Gq
    fig2_egfr
    Accession No. : 1
    PLCbeta
    Pathway No. : 4
    5484explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3
    3Ca.PLC_g  /
    PIP2_hydrolysis
    fig2_egfr
    Accession No. : 1
    PLC_g
    Pathway No. : 10
    97.2222144Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S
    Substrate
    PIP2

    Product
    DAG
    IP3
    4Ca.PLC_g*  /
    PIP2_hydrolysis
    fig2_egfr
    Accession No. : 1
    PLC_g
    Pathway No. : 10
    19.7917574Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S
    Substrate
    PIP2

    Product
    DAG
    IP3



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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