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Molecule Parameter List for mGluRAntag

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
mGluRAntag participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    mGluRAntag acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    mGluRAntag
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • Gq
    Pathway No. : 125
    01000Yes
    I implement this as acting only on the Rec-Gq complex, based on a more complete model PLC_Gq48.g which showed that the binding to the receptor alone contributed only a small amount.

    mGluRAntag acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • Antag-bind-Rec-G
    q
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • Gq
    Pathway No. : 125
    60
    (uM^-1 s^-1)
    0.01
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    Rec-Gq
    mGluRAntag

    Product
    Blocked-rec-Gq
    The rate consts give a total binding affinity of under 0.2 nM, good for a strong antagonist.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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