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Molecule Parameter List for PIP2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PIP2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1004010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    PIP2 acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PIP2
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • PLCbeta
    Pathway No. : 126
    1501000Yes
    PIP2 conc: Willars et al; JBC 273 (9) 27.2.98; pp 5037-5046

    PIP2 acting as a Substrate for an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PLC-Gq  /
    PLC-Gq
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • PLCbeta
    Pathway No. : 126
    5754explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3(145)
        from Smrcka et al, 1991 Science 251: 804-807
    2PLC-Ca  /
    PLC-Ca
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • PLCbeta
    Pathway No. : 126
    19.8408104explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3(145)
        From Sternweis et al Phil Trans R Soc Lond 1992, also matched by Homma et al. k1 = 1.5e-5, now 4.2e-6 k2 = 70/sec; now 40/sec k3 = 17.5/sec; now 10/sec Note that the wording in Sternweis et al is ambiguous re the Km. Also Smrcka et al; Science 251, 15.2.1991, pp804-807
    3PLC-Ca-Gq  /
    PLCb-Ca-Gq
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • PLCbeta
    Pathway No. : 126
    4.999941604explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3(145)
        Km: Sternweis et al, Phil Trans R Soc Lond 1992 Vmax: Smrcka et al, Science 1991
    4PLC  /
    PLC
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • PLCbeta
    Pathway No. : 126
    19.99942.54explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3(145)
        Smrcka et al; Science 251, 15.2.1991, pp804-807

    PIP2 acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    basal
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • PLCbeta
    Pathway No. : 126
    0.003
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    PIP2

    Product
    DAG
    IP3(145)
    accounts for other PLC isoforms that contribute to basal levels of IP3



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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