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Molecule Parameter List for tot_CaM_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
tot_CaM_CaMKII participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1140000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    tot_CaM_CaMKII acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    tot_CaM_CaMKII
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    01000No
    This pool sums the levels of the CaM-bound forms of CaMKII: CaMKII-CaM + CaMKII-thr286*-CaM. Although their phosphorylation states are different, the level of activity is about the same so it makes sense to sum the levels. Hanson et al 1994 Neuron 12:943-956

    tot_CaM_CaMKII acting as a Summed Molecule in  
    Osc_Ca_IP3metabolism Network
    Accession NamePathway NameTargetInput
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM

  • This pool sums the levels of the CaM-bound forms of CaMKII: CaMKII-CaM + CaMKII-thr286*-CaM. Although their phosphorylation states are different, the level of activity is about the same so it makes sense to sum the levels. Hanson et al 1994 Neuron 12:943-956

    tot_CaM_CaMKII acting as an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII /
    CaM_act_305
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    0.0000027056364explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
    2tot_CaM_CaMKII /
    CaM_act_286
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    0.000002705630.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM

  •     See Hanson and Schulman 1992 JBC 267(24):17216-17224
    3tot_CaM_CaMKII /
    CaM-CaMK-phos
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    1.600010.54explicit E-S complexSubstrate
    IP3_3K

    Product
    IP3_3K*
        rates referred from standard CaM-CaMKII phosphorylation rates
    4tot_CaM_CaMKII /
    CaM-CaMK-phos1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    1.599980.54explicit E-S complexSubstrate
    IP3_3K_CaM

    Product
    IP3_3K_CaM*
        rates referred from standard CaM-CaMKII phosphorylation rates



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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