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Molecule Parameter List for tot_autonomous_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
tot_autonomous_CaMKII participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1140000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    tot_autonomous_CaMKII acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    tot_autonomous_CaMKII
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    01000No
    This is the sum total of the various CaM-independent forms of the kinase. There are actually several possible states here, but I only consider the forms thr-286 phosphorylated form and the doubly/triply phosphorylated form including the thr305/306, represented here as CaMKII***

    tot_autonomous_CaMKII acting as a Summed Molecule in  
    Osc_Ca_IP3metabolism Network
    Accession NamePathway NameTargetInput
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    tot_autonomous_CaMKIICaMKII-thr286
    CaMKII***
    This is the sum total of the various CaM-independent forms of the kinase. There are actually several possible states here, but I only consider the forms thr-286 phosphorylated form and the doubly/triply phosphorylated form including the thr305/306, represented here as CaMKII***

    tot_autonomous_CaMKII acting as an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1
  • tot_autonomous_
    CaMKII
     /
    auton_305
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    0.0000041666764explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
    2
  • tot_autonomous_
    CaMKII
     /
    auton_286
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    0.000004166670.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM

  •     The autonomous rate has a slightly higher Km than the CaM-bound rate, but Vmax is the same. Hanson and Schulman 1992 Ann Rev Biochem 61:559-601 and Hanson and Schulman 1992 JBC 267(24):17216-17224
    3
  • tot_autonomous_
    CaMKII
     /
    CaMK-phos
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    2.499990.54explicit E-S complexSubstrate
    IP3_3K

    Product
    IP3_3K*
        rates referred from standard CaMKII phosphorylation rates
    4
  • tot_autonomous_
    CaMKII
     /
    CaMK-phos1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaMKII
    Pathway No. : 121
    2.499950.54explicit E-S complexSubstrate
    IP3_3K_CaM

    Product
    IP3_3K_CaM*
        rates referred from standard CaMKII phosphorylation rates



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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