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Molecule Parameter List for PKC-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-active participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1130000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

PKC-active acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PKC-activefig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 0.021000No

    PKC-active acting as a Summed Molecule in  
    fig2_egfr Network
    Accession NamePathway NameTargetInput
    fig2_egfr
    Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • PKC-activePKC-DAG-AA*
    PKC-Ca-memb*
    PKC-Ca-AA*
    PKC-DAG-memb*
    PKC-basal*
    PKC-AA*

    PKC-active acting as an Enzyme in  
    fig2_egfr Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKC-active /
    PKC-act-raf
    fig2_egfr
    Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 66.666744explicit E-S complexSubstrate
    craf-1

    Product
    craf-1*
    2PKC-active /
    PKC-inact-GAP
    fig2_egfr
    Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
    3PKC-active /
    PKC-act-GEF
    fig2_egfr
    Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 3.3333344explicit E-S complexSubstrate
    inact-GEF

    Product
    GEF*



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.