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Molecule Parameter List for cAMP4.R2C2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
cAMP4.R2C2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
cAMP_pathway25Network
Shared_Object_cAMP_pathway PKA AC 
Gs 
This is a model of the canonical cAMP signaling pathway:
Ligand->Receptor->G-protein->Cyclase->cAMP->PKA.
It also includes phosphodiesterases to balance out cAMP formation.Bhalla US Methods Enzymol. 2002;345:3-23

cAMP4.R2C2 acting as a Molecule in  
cAMP_pathway Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
cAMP4.R2C2cAMP_pathway
Accession No. : 25
PKA
Pathway No. : 135
01000No

cAMP4.R2C2 acting as a Substrate in a reaction in  
cAMP_pathway Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Release-C1cAMP_pathway
Accession No. : 25
PKA
Pathway No. : 135
60
(s^-1)
18
(uM^-1 s^-1)
Kd(cb) = 0.3(uM)-Substrate
cAMP4.R2C2

Product
PKA-active
cAMP4.R2C
This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10

cAMP4.R2C2 acting as a Product in a reaction in  
cAMP_pathway Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • cAMP-bind-site-A
    2
  • cAMP_pathway
    Accession No. : 25
    PKA
    Pathway No. : 135
    75
    (uM^-1 s^-1)
    32.5
    (s^-1)
    Kd(bf) = 0.4333(uM)-Substrate
    cAMP
    cAMP3.R2C2

    Product
    cAMP4.R2C2



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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