NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By


 
Result: 1 - 15 of 15 rows are displayed

Molecule List for pathway MAPK (Pathway Number 139) in Accession MAPK_osc (Accession Number 27)

Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using  and  color.
  NameAccession
Type
Initial
Conc.

(uM)
Volume
(fL)
BufferedSum Total Of
1 MAPKPathway0.30No
    The total concn. of MAPK is 300nM from Kholodenko, 2000.
2 MKKKPathway0.10No
    The total concn. of MKKK is 100nM from Kholodenko, 2000
3 MKKPathway0.30No
    The total concn. of MKK is 300nM from Kholodenko,2000
4 int1Pathway0.0010No
    This is the intermediate enzyme which catalyses the dephosphorylation of MKKK-P to MKKK. The concentration is set to 1 nM based on from Kholodenko, 2000
5 MKKK-PPathway00No
    This is the phosphorylated form of MKKK which converts MKK to MKK-P and then to MKK-PP from Kholodenko, 2000.
6 int3Pathway0.0010No
    This intermediate enzyme catalyses the dephosphorylation of MKK-P to MKK. The concentration is 1nM from Kholodenko, 2000
7 int5Pathway0.0010No
    This catalyses the conversion of MAPK-P to MAPK. The concenration is 1nM. from Kholodenko, 2000
8 MKK-PPathway00No
    This is the single phoshorylated form of MKK. from Kholodenko, 2000.
9 MAPK-PPathway00No
    This is the single phopshorylated form of MAPK from Kholodenko, 2000.
10 int2Pathway0.0010No
    This intermediate enzyme which catalyses the dephosphorylation of MKK-PP to MKK-P. The concentration is 1nM. from Kholodenko, 2000
11 int4Pathway0.0010No
    This intermediate enzyme catalyses the dephosphorylation of MAPK-PP to MAPK-P. The concentration is 1nM. from Kholodenko, 2000
12 Ras-MKKKKPathway0.0010No
    The concn. of Ras-MKKKK* is set to 1 nM implicitly from Kholodenko, 2000
13 
  • inactiveRas-MKKK
  • Pathway00No
        This is the inactive form of Ras-MKKK. Based on the reaction scheme from Kholodenko 2000, this is equivalent to a binding of the MAPK-PP to the Ras. The amount of Ras in the model is small enough that negligible amounts of MAPK are involved in this reaction. So it is a fair approximation to the negative feedback mechanism from Kholodenko, 2000.
    14 MKK-PPPathway00No
        This is the double phosphorylated and active form of MKK from Kholodenko, 2000
    15 MAPK-PPPathway00No
        This is the double phosphorylated and active form of MAPK. from Kholodenko, 2000.

     
    Result: 1 - 15 of 15 rows are displayed



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.