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Molecule List for pathway CaMKII (Pathway Number 235) in Accession AMPAR_traff_model0 (Accession Number 59)

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The entries are grouped according to Pathway Number and are alternately color coded using  and  color.
  NameAccession
Type
Initial
Conc.

(uM)
Volume
(fL)
BufferedSum Total Of
1 
  • basal_CaMKII_
    cyt
  • Network20Yes
    2 
  • basal_CaMKII_
    PSD_control
  • Network20Yes
    3 CaMKIINetwork200No
        Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM.
    4 CaMKII-CaMNetwork00No
    5 
  • CaMKII-thr286*-C
    aM
  • Network00No
        From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
    6 CaMKII***Network00No
        From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
    7 CaMKII-thr286Network00No
        I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
    8 CaMK-thr305Network00No
        This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
    9 
  • CaMKII-thr305-PS
    D
  • Network00No
    10 CaMKII***-PSDNetwork00No
    11 CaMKII-PSDNetwork00No
    12 NMDARNetwork1200No
        The stochiometry is a bit off here. Each NMDAR actually binds to a holoenzyme, about 12 CaMKII subunits. But our CaMKII calculations are in terms of individual subunits. So as a hack, we put in much more NMDAR than is actually there.
    13 
  • CaMKII-thr286-PS
    D
  • Network00No
    14 CaMKII-CaM-PSDNetwork00No
    15 
  • CaMKII-thr286-Ca
    M-PSD
  • Network00No
    16 
  • basal_CaMKII_
    PSD
  • Network20No
    17 tot_CaM_CaMKIINetwork00No CaMKII-CaM
  •  CaMKII-thr286*-C
    aM

  • 18 
  • tot_autonomous_
    CaMKII
  • Network20No CaMKII-thr286
     CaMKII***
  •  basal_CaMKII_
    cyt

  • 19 tot_CaMKII_cytNetwork220No CaMKII-CaM
  •  CaMKII-thr286*-C
    aM

     CaMKII-thr286
     CaMKII***
     CaMK-thr305
     CaMKII
  •  basal_CaMKII_
    cyt

  • 20 act_CaMKII_cytNetwork20No tot_CaM_CaMKII
  •  tot_autonomous_
    CaMKII


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