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Molecule List for pathway CaM (Pathway Number 81) in Accession Synaptic_Network (Accession Number 16) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering. arrow indicates that ordering is done according to ascending or descending order. The entries are grouped according to Pathway Number and are alternately color coded using and color. |
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Name | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of | 1 | CaM | Network | 20 | 0 | No | - | | There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al, Mol Biol. of the Cell, Garland Publishers) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels. | 2 | neurogranin | Network | 10 | 0 | No | - | | Also known as RC3 and p17 and BICKS. Concentration in brain >> 2 uM from Martzen and Slemmon J Neurosci 64 92-100 1995. Concentration in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding. | 3 | neurogranin* | Network | 0 | 0 | No | - | | The phosphorylated form of neurogranin does not bind CaM (Huang et al ABB 305:2 570-580 1993) | 4 | neurogranin-CaM | Network | 0 | 0 | No | - | | This is the CaM-bound form of neurogranin. This CaM is taken out of circulation and thus reduces the signaling through CaM. |
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