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Accession Type:
Network
Osc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
Gq
PLCbeta
134_dephos
 Molecule
 Enzyme
 Reaction
145_dephos
IP4-system
IHP-system
1345_dephos
CaRegulation
Othmer-Tang-mode
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Enzyme List for pathway 134_dephos (Pathway Number 165)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
ip2_3pase1

Enzyme Molecule:
IP2_3pase1
0.799992117.334explicit E-S complexIP2(13)
IP1(1)
  from Caldwell et al, JBC 266; 1991 enzyme activity was assayed for the monomeric form of the enzyme
2 Enzyme Activity:
ip2_3pase2

Enzyme Molecule:
IP2_3pase2
3.7000139.24explicit E-S complexIP2(13)
IP1(1)
  from Caldwell et al, JBC 266; 1991
3 Enzyme Activity:
ip2_4pase

Enzyme Molecule:
IP_4pase
22.9995554explicit E-S complexIP2(34)
IP1(3)
  Ins(34)P2 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994
4 Enzyme Activity:
ip3_4pase

Enzyme Molecule:
IP_4pase
20.0014204explicit E-S complexIP3(134)
IP2(13)
  Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2


Pathway Details   Molecule List  Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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