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Accession Type:
Network
Osc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
Gq
PLCbeta
134_dephos
145_dephos
 Molecule
 Enzyme
 Reaction
IP4-system
IHP-system
1345_dephos
CaRegulation
Othmer-Tang-mode
l

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Enzyme List for pathway 145_dephos (Pathway Number 166)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
ip2_1pase

Enzyme Molecule:
IP_1pase
5.0000524explicit E-S complexIP2(14)
IP1(4)
  from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)
2 Enzyme Activity:
ip3_1pase

Enzyme Molecule:
IP_1pase
20.00214.1254explicit E-S complexIP3(134)
IP2(34)
  Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987
3 Enzyme Activity:
ip3_5pase1

Enzyme Molecule:
IP_5pase1
3.000011.14explicit E-S complexIP3(145)
IP2(14)
  Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987
4 Enzyme Activity:
ip3_5pase2

Enzyme Molecule:
IP3_5pase2
18.000410.6673.99991explicit E-S complexIP3(145)
IP2(14)
  from Hansen et al, JBC 262, 1987 activity determined from pH curve. Value scaled 1.5 times to obtain activity at 37C as original experiment was performed at 30C
5 Enzyme Activity:
ip4_5pase

Enzyme Molecule:
IP_5pase1
0.800030.094explicit E-S complexIP4(1345)
IP3(134)
  Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3


Pathway Details   Molecule List  Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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