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Accession Type:
Network
AMPAR_CaMKII_
weak_coupling
Shared_Object_
AMPAR_CaMKII_
weak_coupling
CaMKII
CaM
PP1
PP2B
PP1_PSD
AMPAR
PKA
 Molecule
 Enzyme
 Reaction
AC
AMPAR_memb
PP1_CaMKII_PSDPP1_CaMKII_PSD
CaMKII_PSD

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Enzyme List for pathway PKA (Pathway Number 288)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
phosph-PDE

Enzyme Molecule:
PKA-active		7.5000894explicit E-S complexcAMP-PDE
cAMP-PDE*
  Same rates as PKA-phosph-I1
2 Enzyme Activity:
PKA

Enzyme Molecule:
PKA-active		7.5002164explicit E-S complexA_B845*
A845*_B845*
3 Enzyme Activity:
PKA-phosph-I1

Enzyme Molecule:
PKA-active		7.5000894explicit E-S complexI1
I1*
  #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
4 Enzyme Activity:
PKA-phosph-I1_
PSD

Enzyme Molecule:
PKA-active		7.5000894explicit E-S complexI1
I1*
5 Enzyme Activity:
PKA[10]

Enzyme Molecule:
PKA-active		7.5002164explicit E-S complexA_B831*
A_B831*845*
6 Enzyme Activity:
PKA[11]

Enzyme Molecule:
PKA-active		7.5002164explicit E-S complexA_B831*
A845*_B831*
7 Enzyme Activity:
PKA[12]

Enzyme Molecule:
PKA-active		7.5002164explicit E-S complexA831*_B831*845*
  • A835*845*_
    B835*845*
    • 8 Enzyme Activity:
    PKA[13]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B831*
  • A835*845*_
    B835*845*
    • 9 Enzyme Activity:
    PKA[14]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*_B831*845*
    10 Enzyme Activity:
    PKA[15]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*845*_B831*
    11 Enzyme Activity:
    PKA[16]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*845*_B
    12 Enzyme Activity:
    PKA[17]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A845*_B
    13 Enzyme Activity:
    PKA[18]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*
    		A845*_B831*
    14 Enzyme Activity:
    PKA[19]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*845*_B831*
    15 Enzyme Activity:
    PKA[1]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B
    		A845*_B845*
    16 Enzyme Activity:
    PKA[20]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A_B845*
    17 Enzyme Activity:
    PKA[21]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*_B845*
    18 Enzyme Activity:
    PKA[22]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*
    		A_B831*845*
    19 Enzyme Activity:
    PKA[23]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*_B831*845*
    20 Enzyme Activity:
    PKA[24]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B845*
    		A845*_B845*
    21 Enzyme Activity:
    PKA[25]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B845*
    		A831*845*_B845*
    22 Enzyme Activity:
    PKA[26]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*845*
    		A845*_B831*845*
    23 Enzyme Activity:
    PKA[27]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*845*
  • A835*845*_
    B835*845*
    • 24 Enzyme Activity:
    PKA[28]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B
    		A845*_B845*
    25 Enzyme Activity:
    PKA[29]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B
    		A831*845*_B845*
    26 Enzyme Activity:
    PKA[2]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A845*_B
    27 Enzyme Activity:
    PKA[30]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B831*
    		A845*_B831*845*
    28 Enzyme Activity:
    PKA[31]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B831*
  • A835*845*_
    B835*845*
    • 29 Enzyme Activity:
    PKA[3]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A_B845*
    30 Enzyme Activity:
    PKA[4]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B845*
    		A831*845*_B845*
    31 Enzyme Activity:
    PKA[5]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B
    		A831*845*_B845*
    32 Enzyme Activity:
    PKA[6]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*_B845*
    33 Enzyme Activity:
    PKA[7]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*845*_B
    34 Enzyme Activity:
    PKA[8]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*845*
    		A845*_B831*845*
    35 Enzyme Activity:
    PKA[9]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B831*
    		A845*_B831*845*


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