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Accession Type:
Network
Ajay_Bhalla_
2004_Feedback_
Tuning
Shared_Object_
Ajay_Bhalla_
2004_Feedback_
Tuning
PKC
PLA2
PLCbeta
 Molecule
 Enzyme
 Reaction
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC

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Enzyme List for pathway PLCbeta (Pathway Number 350)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
PLC-Ca

Enzyme Molecule:
PLC-Ca
19.8413104explicit E-S complexPIP2
DAG
IP3
  From Sternweis et al Phil Trans R Soc Lond 1992, also matched by Homma et al. k1 = 1.5e-5, now 4.2e-6 k2 = 70/sec; now 40/sec k3 = 17.5/sec; now 10/sec Note that the wording in Sternweis et al is ambiguous re the Km.
2 Enzyme Activity:
PLCb-Ca-Gq

Enzyme Molecule:
PLC-Ca-Gq
5.00003484explicit E-S complexPIP2
DAG
IP3
  From Sternweis et al, Phil Trans R Soc Lond 1992, and the values from other refs eg Homma et al JBC 263(14) pp6592 1988 match. k1 = 5e-5/sec k2 = 240/sec; now 120/sec k3 = 60/sec; now 30/sec Note that the wording in Sternweis et al is ambiguous wr. to the Km for Gq vs non-Gq states of PLC. K1 is still a bit too low. Raise to 7e-5 9 Jun 1996: k1 was 0.0002, changed to 5e-5


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