 |  |  CaRegulation |
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Molecule List for pathway CaM (Pathway Number 122) | | Name | Initial Conc. (uM) | Volume (fL) | Buffered | | 1 | CaM | 20 | 1000 | No | | | LOT of this present in the cell: upto 1% of total protein mass. (Alberts et al, Mol Biol of the Cell, Garland Publishers) says 25 uM. Meyer et al, Science 256; 1992: 1199-1202 refer to studies saying it is comparable to CaMK levels. (Kakiuchi et al, J Biochem 92; 1982; 1041-48) say conc in cerebral cortex & cerebellum homogenates: 20-30uM Lower conc in other tissues: lung, adrenal gland, liver, kidney, spleen = 6,5,5,3,2 uM respectively | | 2 | CaM-Ca3 | 0 | 1000 | No | | | The TR1 end now begins to bind Ca. This form has 2 Ca's on the TR2 end, and one on the TR1. | | 3 | CaM-Ca4 | 0 | 1000 | No | | | The four-calcium-bound form of CaM. It is the active form for most reactions. | | 4 | CaM-TR2-Ca2 | 0 | 1000 | No | | | This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not. |
Pathway Details Molecule List Enzyme List Reaction List
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