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Accession Type:
Network
CaMKII_2003
Shared_Object_
CaMKII_2003
CaMKII
 Molecule
 Enzyme
 Reaction
CaM
PP1
PP2B

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Molecule List for pathway CaMKII (Pathway Number 202)

 Name Initial Conc. (uM) Volume (fL) Buffered
1CaMK-thr30601000No
    This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
2CaMKII701000No
    Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM.
3CaMKII***01000No
    From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
4CaMKII-CaM01000No
   
5CaMKII-thr28601000No
    I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
6CaMKII-thr286*-CaM01000No
    From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
7tot_autonomous_CaMKII01000No
   
8tot_CaM_CaMKII01000No
   

Summed Molecule List

  Target Inputs
1 tot_autonomous_CaMKIICaMKII-thr286
CaMKII***
2 tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM



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